Fields of Interest: Clinical Biochemistry, Clinical Chemistry, Toxicology

Please see my website for updates.

http://members.shaw.ca/lyona3/Publications_Andrew_Lyon.html

1.Csorba TR, Lyon AW, Hollenberg MD. Autoimmunity and the pathogenesis of type 1 diabetes. Crit Rev Clin Lab Sci. (in press)


2.M. E. Lyon, D. Gray, L.B. Baskin, J.A. Dubois, AW. Lyon. A mathematical model to assess the influence of hematocrit on point of care glucose meter performance. Clin Biochem. (in press)


3.Lyon AW, James J, Lemaire C, Culleton B. Comparison of the multiple-aliquot and batch methods of monitoring peritoneal dialysis adequacy in patients. Perit Dial Int. 2010; 30: 91-4.


4.Fenton TR, Lyon AW, Eliasziw M, Tough SC, Hanley DA. Phosphate decreases urine calcium and increases calcium balance: A meta-analysis of the osteoporosis acid-ash diet hypothesis. Nutrition J: 2009; 8:41.


5.Fenton TR, Eliasziw M, Lyon AW, Tough SC, Brown JP, Hanley DA. Low 5-year stability of within-patient ion excretion and urine pH in fasting-morning-urine specimens. Nutr Res. 2009; 29(5): 320-6.


6.Higgins T, Saw W, Sikaris K, Cembrowski GC, Lyon AW, Khajuria A, Tran D. Seasonal variation in hemoglobin A1c: Is it the same in both hemispheres? J. Diabetes Sci Technol 2009; 3(4):668-671.

7.Fenton, TR, Lyon AW, Eliasziw M, Tough SC, Hanley DA. A meta-analysis of the effect of the acid-ash hypothesis of osteoporosis on calcium balance. J Bone Min Res. 2009; 24:1835-40.


8.Lyon AW, Higgins TN, Wesenberg JC, Tran DV. Variation in the frequency of HbA1c testing: Population-studies to assess compliance with clinical practice guidelines and use of HbA1c to screen for diabetes. J Diabetes Sci Technol 2009; 3: 411-417.


9.Tran DV, Lyon AW, Higgins TN, Wesenberg JC, Vandergouwe L, Cembrowski GS. Use of serial patient differences of immunoassay and HPLC HbA1c to determine long term instrument performance. J Diabetes Sci Technol 2009; 3: 424-428.


10.Hicks M, Tough SC, Premji S, Benzies K, Lyon AW, Mitchell I, Sauve R. Alcohol and drug screening of newborns: Would women consent? J Obs Gyn Can 2009; 31: 331-339.


11.Kline G, Weeks S, Lyon A, Jamieson P, Kline RL. A case of acquired salt-wasting orthostasis due to a syndrome of inappropriate cardiac natriuretic peptides secretion. Clin Chim Acta 2009; 401:184-6.


12.James MT, Zhang J, Lyon AW, Hemmelgarn BR. Reduction in misclassification of calcium status through application of a local equation for albumin adjusted calcium. BMC Clinical Pathology 2008, 8:12.


13.Fenton TR, Tanis R Fenton, Michael Eliasziw, Andrew W Lyon, Suzanne C Tough, David A Hanley. A meta-analysis of quantity of calcium excretion associated with the net acid excretion of the modern diet under the acid-ash diet hypothesis Am J. Clin Nutri 2008 88:1159-66


14.Manley SA, Byrns S, Lyon AW, Brown P, Gailer J. Simultaneous Cu, Fe and Zn-specific detection of plamsa metalloproteins by size exclusion chromatography-inductively coupled plasma atomic emission spectroscopy. J Biol Inorg Chem. 2009; 14(1): 159.


15.Hansson P, Lyon A. Hur kan man leva utan albumin? Nagra fall av analbuminemi vacker patofysiologiska fragor How is it possible to live without albumin? Several recent cases of analbuminemia raise physiopathological questions. Lakartidningen 2008; 105(23): 1768-70.

16.Csorba TR, Lyon AW. Abnormal proinsulin congeners as autoantigens that initiate the pathogenesis of Type I diabetes. Medical Hypotheses 2005; 64:186-191.


17.Lyon AW, Larsen ET, Edwards AL. The impact of new guidelines for glucose tolerance testing on clinical practice and laboratory services.CMAJ. 2004 Oct 26;171(9):1067-9.


18.Lyon ME, Ball CL, Krause RD, Slotsve GA, Lyon AW. Effect of hemolysis on cardiac Troponin T determination by the Elecsys. 2010 Immunoanalyzer Clin Biochem 2004; 37(8): 698-701.


19.Newstead J, Card S, Lyon AW. Low serum albumin and abnormal body shape in a young Canadian First Nations woman. Lab Med. 2004; 35(6): 350-356.


20.Lyon AW, Whitley C, Eintracht SL. Analytical evaluation and application of a novel spectrophotometric serum lithium method to a rapid response laboratory. Ther Drug Monit. 2004; 26: 98-101.


21.Hicks M, Sauve RS, Lyon AW, Clarke M, Tough S. Alcohol use and abuse in pregnancy: An evaluation of the merits of screening. Can Child Adol Psych Rev 2003; 12: 77-80.


22.Campagnoli M, Kragh-Hansen U, Overgaard Pedersen A, Amoresano A, Lyon AW, Cesati R, Sala A, Romano A, Galliano M, and Minchiotti L. Structural analysis, fatty acid and thyroxine binding properties of Vancouver and Naskapi variants of human serum albumin. Clin Biochem 2003; 36: 597-605.


23.Lyon ME, Ball CL, Lyon AW, Walpole E, Church DL. A preliminary evaluation of the interaction between urine specific gravity and leukocyte esterase results using Bayer Multistix and the Clinitek 500. Clin Biochem 2003; 35: 579-81.


24.Lyon AW, Baskin LB. Pseudohyponatremia in a Myeloma Patient: Direct Electrode Potentiometry is a Method Worth its Salt. Lab Med. 2003. 34(5): 357-60.


25.Lyon AW, Mayhew WJ. Cesium toxicity: a case of self-treatment by alternate therapy gone awry. Ther Drug Monit. 2003 Feb;25(1):114-6.

26.Zhang Z, Juurlink BHJ, Lyon AW, Paterson PG. Effects of dietary protein and L-2-oxothiazolidine-4-carboxylate on rat brain glutathione concentration. Nutrition Research 2002, 22: 1475-86.

27.Lyon AW, Mansoor A, Trotter MJ. Urinary Gems, Acyclovir Crystalluria , Arch Path Lab Med 2002; 126: 753-4.

28.Galliano M, Campagnoli M, Rossi A, Wirsing von Konig CH, Lyon AW, Cefle K, Yildiz A, Palanduz S, Ozturk S, Minchiotti L. Molecular diagnosis of analbuminemia: a novel mutation identified in two Amerindian and two Turkish families. Clin Chem. 2002 ;48:844-9.

29.Paterson PG, Juurlink BHJ, Lyon AW, Kamencic H, Andersen LB. Sulfur amino acid deficiency depresses brain glutathione concentration. Nutr Neurosci. 2001; 4(3):213-22.


30.Katrusiak A.E, Paterson P.G, Kamencic H, Shoker A, Lyon A.W. A UV-HPLC method for determination of total and reduced cysteine, cystinylglycine, homocystine and glutathione in plasma and cells extracts. J Chromatography B. Biomed Sci Appl (2001) 758: 207-212.

31.Kamencic H, Griebel RW, Lyon AW, Paterson PG, BHJ Juurlink (2001), Promoting glutathione synthesis following spinal cord trauma decreases secondary damage and promotes retention of function. FASEB Journal 15: 243-250.

32.Kamencic H, Lyon A, Paterson P.G., Juurlink BHJ. 2000 Monochlorobimane fluorometric method to measure tissue glutathione Anal Biochem 286:35-7.

33.Lyon ME, Rutledge Harding S, Oosman SN, Lyon AW. 2000 Evaluation of Argatroban and DuP714 as anticoagulants for blood gas, electrolyte and ionized calcium analyses. Scand. J. Clin. Labs. Invest. 60: 19-26.

34.Lyon ME, Drobot DW, Harding SR, Lyon AW. Evaluation of the thrombin inhibitor D-phenylalanyl-L-prolyl-L-arginine chloromethylketone (PPACK) with the factor Xa inhibitor 1,5-dansyl-L-glutamyl-L-glycyl-L-arginine chloromethylketone (GGACK)
as anticoagulants for critical care clinical chemistry specimens. Clin Chim Acta 1999;280(1-2):91-9.

35.Lyon AW, Meinert P, Bruce GA, Laxdal VA, Salkie ML. Influence of methodology on the detection and diagnosis of congenital analbuminemia. Clin. Chem. 1998; 44: 2365-7.

36.Lyon AW, Rutledge Harding S, Drobot D, Lyon ME. 1997 "Use of thrombin inhibitors ex vivo allows critical care clinical chemistry and hematology testing in common specimens" Clin Biochem 30:121-128.

37.Hindmarsh JT, Lyon AW. 1996. Strategies to improve the utilization of clinical chemistry services. Clinical Biochemistry 29:291-300

38.Lyon ME, Fine JS, Henderson, PJ, Lyon AW. 1995. D-phenylalanyl-L-prolyl-Larginine chloromethylketone
(PPACK) is an alternative anticoagulant to heparin salts for blood gas, electrolyte and ionized calcium specimens. Clinical Chemistry 41:1038-41

39.Lyon AW, Duran G, Raisys VA. 1995. "Determination of thalidomide by high performance liquid chromatography: methodological strategy for clinical trials". Clinical Biochemistry 28: 467-470

40.Lyon AW, Greenway DC, Hindmarsh JT. 1995. "A strategy to promote rational clinical chemistry test utilization". American Journal Clinical Pathology 103: 718-724

41.Lyon AW, Schaan B, Laxdal VA, Massey KLM. 1995. Evaluation of an Immunoturbidimetric Assay for Hemoglobin Alc. Clinical Biochemistry 28(1): 97-100

42.Lyon AW, Anastassiades T, Kisilevsky R. 1993. In vivo analysis of murine serum sulphate metabolism and splenic glycosaminoglycan biosynthesis during acute inflammation and amyloidosis. Journal of Rheumatology 20:1108-1113

43.Kisilevsky R, Lyon AW, Young ID. 1992. A critical analysis of postulated pathogenic mechanisms in amyloidosis. Critical Reviews in Laboratory Medicine 29:59-82

44.Dow KE, Riopelle RJ, Szarek WA, Bols M, Ison ER, Plenkiewicz J, Lyon A, Kisilevsky R. 1992. Effects of 4-deoxy-L-threo-pentose, a novel carbohydrate on neural cell proteoglycan synthesis and function. Biochimica et Biophysica Acta 1156:7-14

45.Lyon AW, Narindrasorasak S, Anastassiades T, Couchman JR, McCarthy K, Kisilevsky R. 1991. Co-deposition of basement membrane components during the induction of murine splenic AA amyloid. Laboratory Investigation 64:785-790

46.Lyon AW, Kisilevsky R. 1990. Inhibition of the initiation of hepatic protein synthesis during ethionine mediated ATP depletion in vivo: Modification to ribosomal subunits, evidence of impaired ternary complex formation and a subcellular redistribution of eIF-2 alpha. Biochimica Biophysica Acta 1049:158-170

47.Lyon AW, Kisilevsky R. 1986. Changes in glucose metabolism following the administration of ethionine: Its role in regulating hepatic protein synthesis. Toxicological Pathology 14:424-428

Katrusiak AE, Paterson PG, Kamencic H, Shoker A, Lyon AW
Pre-column derivatization high-performance liquid chromatographic method for determination of cysteine, cysteinyl-glycine, homocysteine and glutathione in plasma and cell extracts.
J Chromatogr B Biomed Sci Appl. 2001 Jul 15;758(2):207-12.
Abstract

Kamencic H, Griebel RW, Lyon AW, Paterson PG, Juurlink BH
Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function.
FASEB J. 2001 Jan;15(1):243-250.
Abstract

Lyon ME, Harding SR, Oosman SN, Lyon AW
Evaluation of argatroban and DUP 714 as anticoagulants for blood gas, electrolyte and ionized calcium analyses.
Scand J Clin Lab Invest. 2000 Feb;60(1):19-25.
Abstract

Lyon AW
Acute coronary syndromes.
Lancet. 1999 Sep 4;354(9181):867.


Lyon ME, Drobot DW, Harding SR, Lyon AW
Evaluation of the thrombin inhibitor D-phenylalanyl-L-prolyl-L-arginine chloromethylketone (PPACK) with the factor Xa inhibitor 1,5-dansyl-L-glutamyl-L-glycyl-L-arginine chloromethylketone (GGACK) as anticoagulants for critical care clinical chemistry specimens.
Clin Chim Acta. 1999 Feb;280(1-2):91-9.
Abstract

Lyon AW, Meinert P, Bruce GA, Laxdal VA, Salkie ML
Influence of methodology on the detection and diagnosis of congenital analbuminemia.
Clin Chem. 1998 Nov;44(11):2365-7.


Lyon AW, Harding SR, Drobot D, Lyon ME
Use of thrombin inhibitors ex vivo allows critical care clinical chemistry and hematology testing on common specimens.
Clin Biochem. 1997 Mar;30(2):121-7.
Abstract

Hindmarsh JT, Lyon AW
Strategies to promote rational clinical chemistry test utilization.
Clin Biochem. 1996 Aug;29(4):291-9.
Abstract

Lyon AW, Duran G, Raisys VA
Determination of thalidomide by high performance liquid chromatography: methodological strategy for clinical trials.
Clin Biochem. 1995 Aug;28(4):467-70.


Lyon AW
The luxury of bedside testing.
Am J Clin Pathol. 1995 Jul;104(1):107-8.


Lyon ME, Fine JS, Henderson PJ, Lyon AW
D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK): alternative anticoagulant to heparin salts for blood gas and electrolyte specimens.
Clin Chem. 1995 Jul;41(7):1038-41.
Abstract

Lyon AW, Greenway DC, Hindmarsh JT
A strategy to promote rational clinical chemistry test utilization.
Am J Clin Pathol. 1995 Jun;103(6):718-24.
Abstract

Lyon AW, Schaan B, Laxdal VA, Massey KL
Evaluation of an immunoturbidimetric assay for hemoglobin A1c.
Clin Biochem. 1995 Feb;28(1):97-100.


Lyon AW, Anastassiades T, Kisilevsky R
In vivo analysis of murine serum sulfate metabolism and splenic glycosaminoglycan biosynthesis during acute inflammation and amyloidosis.
J Rheumatol. 1993 Jul;20(7):1108-13.
Abstract

Kisilevsky R, Lyon AW, Young ID
A critical analysis of postulated pathogenetic mechanisms in amyloidogenesis.
Crit Rev Clin Lab Sci. 1992;29(1):59-82.
Abstract

Lyon AW, Narindrasorasak S, Young ID, Anastassiades T, Couchman JR, McCarthy KJ, Kisilevsky R
Co-deposition of basement membrane components during the induction of murine splenic AA amyloid.
Lab Invest. 1991 Jun;64(6):785-90.
Abstract

Lyon AW, Kisilevsky R
Inhibition of the initiation of hepatic protein synthesis during ethionine mediated ATP depletion in vivo: modification to ribosomal subunits, evidence of impaired ternary complex formation and a subcellular redistribution of eIF-2 alpha.
Biochim Biophys Acta. 1990 Jun 21;1049(2):158-70.
Abstract

Lyon AW, Kisilevsky R
Rapid changes in glucose metabolism following the administration of ethionine: its role in regulating hepatic protein synthesis.
Toxicol Pathol. 1986;14(4):424-9.
Abstract

Kamencic H, Lyon A, Paterson PG, Juurlink BH
Monochlorobimane fluorometric method to measure tissue glutathione.
Anal Biochem. 2000 Nov 1;286(1):35-7.
Abstract

Dow KE, Riopelle RJ, Szarek WA, Bols M, Ison ER, Plenkiewicz J, Lyon A, Kisilevsky R
Effects of 4-deoxy-L-threo-pentose, a novel carbohydrate, on neural cell proteoglycan synthesis and function.
Biochim Biophys Acta. 1992 Dec 8;1156(1):7-14.
Abstract