Fields of Interest: Parkinson's disease and Schizophrenia

Spanish Version

Dr. de Erausquin graduated from the School of Medicine of the Universidad de Buenos Aires, in Argentina, in 1986. He received a Fellowship from the Council of Scientific and Technological Research of Argentina to complete graduate studies in Behavioral Pharmacology at the same university, and received a Ph.D. in 1990. After two years of post-doctoral training at the Fidia-Georgetown Institute for the Neurosciences in Washington, D.C., he moved to Yale University, where he completed a residency in Psychiatry and a fellowship in Biochemical Brain Imaging, funded by the Veterans Administration. He then trained in Neurology at Washington University, where he joined the faculty after graduation and was promoted to the rank of Associate Professor of Psychiatry and Neurology. In 2009 he moved to Harvard Medical School, where he became Clinical Director of Neuromodulation of the Institute of Neurosciences at the Brigham and Women's Hospital, and codirector of the Laboratory of Brain Development, Modulation and Repair. Dr. de Erausquin has received several prestigious awards for his research, including the Young Investigator Award of the International Society of Schizophrenia, the APA-Dista Residents Research Award of the American Psychiatric Association, the S Weir Mitchell Award of the American Academy of Neurology, the Joint Junior Faculty Award of the United Parkinson Foundation and the Parkinson Disease Foundation, and the NARSAD Klerman Award in Clinical Psychiatry. He has been Stephen and Constance Lieber Investigator, and Syndey R. Baer Jr. Investigator.

Aleman GG, de Erausquin GA, Micheli F
Cognitive disturbances in primary blepharospasm.
Mov Disord. 2009 Oct 30;24(14):2112-20.
Abstract

Anastasia A, Torre L, de Erausquin GA, Masco DH
Enriched environment protects the nigrostriatal dopaminergic system and induces astroglial reaction in the 6-OHDA rat model of Parkinson’s disease.
J Neurochem. 2009 May;109(3):755-65. Epub 2009 Feb 20.
Abstract

Zorumski CF, de Erausquin G, Dokucu M, Svrakic D, Garcia K, Jarvis M
Brain stimulation & the treatment of refractory psychiatric disorders.
Mo Med. 2008 Jan-Feb;105(1):57-61.
Abstract

Tabbal SD, Revilla FJ, Mink JW, Schneider-Gibson P, Wernle AR, de Erausquin GA, Perlmutter JS, Rich KM, Dowling JL
Safety and efficacy of subthalamic nucleus deep brain stimulation performed with limited intraoperative mapping for treatment of Parkinson’s disease.
Neurosurgery. 2007 Sep;61(3 Suppl):119-27; discussion 127-9.
Abstract

Anastasia A, de Erausquin GA, Wojnacki J, Masco DH
Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson’s disease.
J Neurochem. 2007 Nov;103(4):1542-52. Epub 2007 Sep 13.
Abstract

Mamah D, Wang L, Barch D, de Erausquin GA, Gado M, Csernansky JG
Structural analysis of the basal ganglia in schizophrenia.
Schizophr Res. 2007 Jan;89(1-3):59-71. Epub 2006 Oct 30.
Abstract

Dorsey DA, Masco DH, Dikranian K, Hyrc K, Masciotra L, Faddis B, Soriano M, Gru AA, Goldberg MP, de Erausquin GA
Ultrastructural characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death in embryonic dopaminergic neurons.
Apoptosis. 2006 Apr;11(4):535-44.
Abstract

Calvo de Padilla M, Padilla E, Gonzalez Aleman G, Bourdieu M, Guerrero G, Strejilevich S, Escobar JI, Svrakic N, Cloninger CR, de Erausquin GA
Temperament traits associated with risk of schizophrenia in an indigenous population of Argentina.
Schizophr Res. 2006 Apr;83(2-3):299-302. Epub 2006 Feb 9.


Strejilevich SA, Palatnik A, Avila R, Bustin J, Cassone J, Figueroa S, Gimenez M, de Erausquin GA
Lack of extrapyramidal side effects predicts quality of life in outpatients treated with clozapine or with typical antipsychotics.
Psychiatry Res. 2005 Feb 28;133(2-3):277-80.
Abstract

de Erausquin GA
Transactivation of cell death signals by glutamate transmission in dopaminergic neurons.
Crit Rev Neurobiol. 2004;16(1-2):107-19.
Abstract

Zhang PL, Santos JM, Newcomer J, Pelfrey BA, Johnson MC, de Erausquin GA
Impact of atypical antipsychotics on quality of life, self-report of symptom severity, and demand of services in chronically psychotic patients.
Schizophr Res. 2004 Nov 1;71(1):137-44.
Abstract

Moulder KL, Meeks JP, Shute AA, Hamilton CK, de Erausquin G, Mennerick S
Plastic elimination of functional glutamate release sites by depolarization.
Neuron. 2004 May 13;42(3):423-35.
Abstract

Bremner JD, Bronen RA, De Erasquin G, Vermetten E, Staib LH, Ng CK, Soufer R, Charney DS, Innis RB
Development and Reliability of a Method for Using Magnetic Resonance Imaging for the Definition of Regions of Interest for Positron Emission Tomography.
Clin Positron Imaging. 1998 Jun;1(3):145-159.
Abstract

de Erausquin GA, Hyrc K, Dorsey DA, Mamah D, Dokucu M, Masco DH, Walton T, Dikranian K, Soriano M, Garcia Verdugo JM, Goldberg MP, Dugan LL
Nuclear translocation of nuclear transcription factor-kappa B by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors leads to transcription of p53 and cell death in dopaminergic neurons.
Mol Pharmacol. 2003 Apr;63(4):784-90.
Abstract

Abi-Dargham A, Laruelle M, Krystal J, D’Souza C, Zoghbi S, Baldwin RM, Seibyl J, Mawlawi O, de Erasquin G, Charney D, Innis RB
No evidence of altered in vivo benzodiazepine receptor binding in schizophrenia.
Neuropsychopharmacology. 1999 Jun;20(6):650-61.
Abstract

Abi-Dargham A, Gandelman MS, DeErausquin GA, Zea-Ponce Y, Zoghbi SS, Baldwin RM, Laruelle M, Charney DS, Hoffer PB, Neumeyer JL, Innis RB
SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT.
J Nucl Med. 1996 Jul;37(7):1129-33.
Abstract

Isaacs KR, de Erausquin G, Strauss KI, Jacobowitz DM, Hanbauer I
Differential effects of excitatory amino acids on mesencephalic neurons expressing either calretinin or tyrosine hydroxylase in primary cultures.
Brain Res Mol Brain Res. 1996 Feb;36(1):114-26.
Abstract

de Erausquin G, Brooker G, Costa E, Hanbauer I
Persistent AMPA receptor stimulation alters i homeostasis in cultures of embryonic dopaminergic neurons.
Brain Res Mol Brain Res. 1994 Feb;21(3-4):303-11.
Abstract

de Erausquin G, Brooker G, Hanbauer I
K(+)-evoked dopamine release depends on a cytosolic Ca2+ pool regulated by N-type Ca2+ channels.
Neurosci Lett. 1992 Oct 12;145(2):121-5.
Abstract

de Erausquin GA, Manev H, Guidotti A, Costa E, Brooker G
Gangliosides normalize distorted single-cell intracellular free Ca2+ dynamics after toxic doses of glutamate in cerebellar granule cells.
Proc Natl Acad Sci U S A. 1990 Oct;87(20):8017-21.
Abstract