Fields of Interest: neurophysiology, neuropharmacology, cerebral ischemia, aging

Personal background: Born 20 February 1947 in Sofia, Bulgaria.
Graduated from the Higher Leningrad Electrotechnical Institute, St. Petersbourg, Russia, 1964 - 1970. Speciality: Electronics in Medicine.


Current affiliation and post: Associate Professor, Head of the Department "Neurobiology of Adaptation processes" and of the Laboratory "Integrative Neuropharmacology",Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia

Working address: Dr. Slavianka Moyanova, Acad. G. Bonchev Str. 23, Institute of Neurobiology, BAS,1113 Sofia, Bulgaria
Tel: +359 2 979 3756; email: slav@bio.bas.bg

Languages: Mothertongue: Bulgarian. Fluent in English, French and Russian

Fields of Professional Interest: Neuropharmacology, Neurophysiology

Professional qualifications:

1970-1973: Diplome Biomedical Engineer in the Institute of Physiology,
Bulgarian Academy of Sciences, Sofia
1973-1977: Graduate student in Neurophysiology in the Central Laboratory for Brain Research,BAS, Sofia, Bulgaria,1977:
1977: Ph.D. in Biology; Dissertation: Neurophysiological analysis of the genesis of the spindle-like barbiturate bioelectrical activity in the somatosensory cortex.
1977: Fellowship in IBRO UNESCO Training Course in
Pharmacology, Leipzig, Germany.
1978: Fellowship in the Instutute of Physiology, Tbilissi, Georgia.
1978 - 1989: Research Fellow in Physiology, Institute of Physiology, BAS,Sofia, Bulgaria
1979-1980: Visiting Research Scientist in the Laboratory of Neurophysiology, CNRS, Gif-sur-Yvette, France, Grant: C.I.E.S.
since 1989: Associate Professor in Pharmacology in the Laboratory of Pharmacology of the Central Nervous System (renamed to Laboratory of Integrative Neuropharmacology),Institute of Physiology (renamed to Institute of Neurobiology), Bulgarian Academy of Sciences, Sofia



Member of:
1. International Brain Research Organization (IBRO)
2. European Brain Behavior Society (EBBS)
3. International Pharmaco-EEG Society (IPEG)
4. Bulgarian Union of Scientists
5. Bulgarian Society of Neurosciences
6. Bulgarian Pharmacological Society
7. Bulgarian Physiological Society
8. Bulgarian Society of EEG, EMG and Clinical
Neurophysiology


Publications: 76
Selected articles in journals, published in Medline:

1. Moyanova S., Atsev, V. Maloletnev V. Background neuronal activity in the cat somatosensory cortex before and after VPL damage. Histogram and taxonomic analysis. Acta Physiol. Pharmacol. Bulg. 4, 1978, 43-50.

2. Atsev E., V. Petkov, S. Moyanova, T. Yossifov, D. Itsev. Behavioral reactions and changes of spontaneous and evoked EEG activity after microinjections of noradrenaline and isoprenaline into cat nucleus Raphe dorsalis. Acta Physiol. Pharmacol. Bulg., 5 (2), 1979, 53-61.

3. Champagnat J., M. Denavit-Saubie, S. Moyanova, G. Rondouin, E. Boudinot. Inhibitory aminoacids and periodic discharges of respiratory neurones in the medulla of the cat. In: Amino-Acid Neurotransmitters. Adv.in Biochem. Psychopharmacol., Vol. 29, F. V. de Feudis and P. Mendel (Eds.), Raven Press, New York, 1981, pp. 89-96.

4. Champagnat J., M. Denavit - Saubie, S. Moyanova, G. Rondouin. Involvement of aminoacids in periodic inhibitions of bulbar respiratory neurones. Brain Res., 237, 1982, 351-365.

5. Dimov S., R. Nikolov, M. Nikolova, S. Moyanova. Effect of piracetam in some models of general and local depressions of the cortical bioelectrical activity in cats. Arch. Int. Pharmacodyn., 262, 1983, 13-23.

6. Dimov S., M. Nikolova, R. Nikolov, S. Moyanova. Effect of aligeron and cinnarizine in models of general and local depression of the cortical bioelectrical activity in cats. Meth. Find. Exp. Clin. Pharmacol.,5, 1983, 89-95.

7. Moyanova S., T. Yossifov, D. Popivanov, S. Dimov, V. Petkov. Electrophysiological effects of propranolol and carbachol locally injected into nucleus raphe dorsalis in cats. Meth. Find. Exp. Clin. Pharmacol., 5, 1983, 149-161.

8. Moyanova S., D. Popivanov, D. Itsev. Evoked potentials and rhythmic afterpotentials in relation to prestimulus EEG activity during quiet waking state. Acta Physiol. Pharmacol. Bulg. 9, 1983, 3-11.

9. Moyanova S. Rhythmic afterpotentials in relation to prestimulus barbiturate spindle-like activity. Macro and micro-electrode investigations. Acta Physiol. Pharmacol. Bulg., 9, 1983, 12-20.

10. Dimov S., S. Moyanova, R. Nikolov, M. Nikolova. Piracetam and brain excitability. An electro-physiological study in cats. Meth. Find. Exp. Clin. Pharmacol., 6, 1984, 83-90.

11. Kaijima M., D. Riche, S. Rousseva, S. Moyanova, Dimov S., Le Gal La Sale G. Electroencephalographic, behavioral and histopatological features of seizures induced by intra-amigdaloid application of folic acid in cats. Exp. Neurology, 86, 1984, 313-321.

12. Morin-Surun, M. P., J. Champagnat, M. Denavit-Saubie, S. Moyanova. The effects of acetylcholine on bulbar respiratory-related neurones: Consequences of anesthesia by pentobarbital. Naunyn-Schmiedeberg's Arch. Pharmacol., 325, 1984, 205-208.

13. Moyanova S., R. Nikolov, S. Dimov. Effect of piracetam on the electrocorticogram after traumatic brain oedema in cats. Meth. Find. Exp. Clin. Pharmacol., 7, 1985, 623-626.

14. Moyanova S., S. Dimov. Modulation of visual excibatility cycles in some brain structures by high frequency stimulation of raphe dorsal nucleus in cats. Acta. Physiol. Pharmacol. Bulg., 12 (1), 1986, 17-25.

15. Moyanova S., S. Rousseva, A. Ivanova, S. Dimov. Intraraphe-dorsal kainic acid induces paroxysmal electroencephalographic changes in some brain structures of cats. Exp. Neurology, 92, 1986, 98-109.

16. Moyanova S., S. Rousseva, S. Dimov. Changes in the EEG reactions to repetitive peripheral and central elecrical stimulation by intraraphedorsal kainic acid in the cats. Meth. Find. Exp. Clin. Pharmacol., 9, 1987, 39-47.

17. Moyanova S., S. Dimov, A. Ivanova. Kainic acid microinjected into the cat raphe dorsal nucleus modulates the somatosensory evoked potentials and thier cycles of excitability. Neuroscience, 22, 1987, 83-89.

18. Getova D., S. Moyanova. Anticonvulsive effect of 2-hydroxylamine-5 ethyl-5 sec. pentil barbituric acid in two experimental models of epilepsy. Meth. Find. Exp. Clin. Pharmacol., 10, 1988, 267-272.

19. Moyanova S., Ta L. Dorsal raphe stimulation modulates responses of substantia nigra, pars reticulata neurons to painful stimulation. Acta Physiol. Pharmacol. Bulg., 14 (2), 1988, 24-32.

20. Moyanova S., S. Dimov, D. Popivanov. Allylglicine and brain excitability. Electrophysiological investigations in cats. Acta Physiol. Pharmacol. Bulg., 15(1), 1989, 47-53.

21. Moyanova S., S. Rousseva. Amphetamine stereotypy in cats and neurotransmitter interactions in the caudate nucleus: I. Effects of intracaudate injections of haloperidol, GABA and bicuculine. Acta Physiol. Pharmacol. Bulg., 15(1), 1989, 54-62.

22. Moyanova S., S. Rousseva. Amphetamine stereotypy in cats and neurotransmitter interactions in the caudate nucleus: II. Effects of intracaudate injections of leu-enkephalin and naloxone. Acta Physiol. Pharmacol. Bulg., 15(2), 1989, 47-52.

23. Moyanova S., S. Rousseva. Amphetamine stereotypy in cats and neurotransmitter interactions in the caudate nucleus: III. Effects of intracaudate injections of quipazine, cyproheptadine and electrical stimulation of the raphe dorsal nucleus. Acta Physiol. Pharmacol. Bulg., 15(3), 1989, 43-49.

24. Dikova M., S. Moyanova, M. Nikolova. Quantitative EEG analysis of the effects of nicergoline in some brain structures after asphyxic anoxia in cats. Biomed. Biochim. Acta, 48, 1989, S227-S230.

25. Getova D., S. Moyanova, V. Georgiev, V. Ivanova. Anticonvulsive activity of a barbiturate derivative HB-7 in a model of allylglycine-induced epilepsy in cats. Acta Physiol. Pharmacol. Bulg., 1990, 16 (3), 43-49.

26. Moyanova S., D. Riche. Effect of kainic acid into the raphe dorsal nucleus on sleep stages in cats. Acta Neurobiol. Exp., 1991, 51, 37-44.

27. Moyanova S., D. Riche. Injections of kainic acid into the raphe dorsal nucleus in freely moving cats: electroencephalographic, behavioural and histopathological consequences. Meth. Find. Exp. Clin. Pharmacol., 1992, 14, 49-60.

28. Nikolov R., J. Maslarova., I. Semkova., S. Moyanova. Intracerbroventricular endothelin-1 (ET-1) produces CA 2+-mediated antinociception in mice. Meth. Find. Exp. Clin. Pharmacol., 1992, 14, 229-233.

29. Nikolov R., I. Semkova, J. Maslarova, S. Moyanova Antinociceptive effect of centrally administered endothelin-1 and endothelin-3 in the mouse. Meth. Find. Exp. Clin. Pharmacol., 15, 1993, 447-453.

30. Kirov R., S. Moyanova. Ritanserin-induced changes in sleep-waking phases in rats. Acta Physiol. Pharmacol. Bulg. 21(4), 1995, 87-92.

31. Moyanova S., R. Kirov R., V. Ivanova. Power spectral electroencephalogram analysis of the effects of ritanserin in freely moving rats during quiet waking. Meth Find. Exp. Clin Pharmacol., 19 (9), 1997, 605-611.

32. Kirov R., S. Moyanova. Age-dependent effects of ketanserin on the sleep-waking phases in rats. Intern. J. Neuroscience, 93 (3-4), 1998, 257-264.

33. Kirov R., S. Moyanova. Age-related effect of ritanserin on the sleep-waking phases in rats. Intern. J. Neuroscience, 93 (3-4), 1998, 265-278.

34. Moyanova S., L. Kortenska, R. Kirov. High-voltage electroencephalogram spindles, aging and 5-HT2 antagonism. Brain Research, 786, 1998, 55-63.

35. Moyanova S., L. Kortenska, R. Kirov, I. Iliev. Quantitative electroencephalographic changes due to middle cerebral artery occlusion by endothelin-1 in conscious rats. Arch. Physiol. Biochem. 106 (5), 1998, 384-391.

36. Moyanova S., R. Kirov, L. Kortenska. Age-related changes in neocortical high-voltage spindles and alpha EEG power during quiet waking in rats. Intern. J. Neuroscience 2002, 112, 473-487.

37. Kirov R., S. Moyanova. Distinct sleep-wake stages in rats depend differentially on age. Neuroscience Letters 2002, 322, 134-136.

38. Moyanova S., R.Kirov, L.Kortenska. Multi-unit activity suppression and sensorimotor deficits after endothelin-1 induced middle cerebral artery occlusion in conscious rats. J. of the Neurol. Sciences, 2003, 212, 59-67.

39. Moyanova S., L. Kortenska, R. Mitreva. Endothelin-1-induced cerebral ischemia: Effects of ketanserin and MK-801 on limb placing in rats. Int. J. Neuroscience, 2007, 117, 1361-1381.

40. Moyanova S., L. Kortenska, R. Mitreva, V. Pashova, R. Ngomba, F. Nicoletti. Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 2007, 1153, 58-67.

41. Moyanova S.G., L.V. Korenska, R.K. Kirov, D.E. Itzev, K.G. Usunoff. Ketanserin reduces the postischemic EEG and behavioural changes following Endothelin-1-induced occlusion of the middle cerebral artery in conscious rats. Centr. European J. Medicine, 3(4), 2008, 406-416.

42. Mastroiacovo F., C.L. Busceti, F. Biagioni, S.G. Moyanova, M.H. Meisler, G. Battaglia, A. Caricasole, V. Bruno V, F. Nicoletti. Induction of the WNT antagonist, DICKKOPF-1 contributes to the development of neuronal death in models of brain focal ischemia. J. Cerebr. Blood Flow Metab., 29 (2), 2009, 264-276.

43. Nikolova S., S. Moyanova, S. Hughes, M. Bellyou-Camilleri, T.-Y. Lee, R. Bartha. Endothelin-1 induced MCAO: Dose dependency of cerebral blood flow. J. Neurosci. Methods, 179, 2009, 22-28.



Main published contributions to scientific meetings:

1. Moyanova S. On the participation of the thalamic relay nuclei in the spindling in the somatosensory area of the cat brain cortex. XXVII Intern. Congress of Physiol. Sciences, Paris, 1977. Abstract in the Proceedings of the International. Union of Physiol. Sciences, Paris, France, vol.13, 1977, p.532

2. Atsev E., Moyanova S. The rhythmic afterdischarge as a sign of thalamocortical relationships. Simultaneous macro- and microelectrode studies. XXVII Intern. Congress of Physiological Sciences, Paris, 1977, Abstract in the Proceedings of the International Union of Physiol. Sciences, Paris, France, vol. 13, 1977, p.37.

3. Champagnat J., Rondouin G., Moyanova S., Denavit-Saubie M. Periodic inhibitions of bulbar respiratory neurones and pentobarbital anaesthesia. XXVIII Intern. Congress of Physiol. Sciences, Budapest, Hungary, 1980. Abstract in the Proceedings of the Intern. Union of Physiol. Sciences, vol. XIV, 1980, p.353.

4. Dimov S., Moyanova S., Nikolov R., Nikolova M. Neurophysiological analysis of piracetam effects on the memory processes. Annual General Conference of the European Brain and Behaviour Society, London, England, 1981. Abstract in Behav. Brain Research, 5(1), 1982, 98-99.

5. Moyanova S., Dimov S., Nikolov R., Rousseva S., Nikolova M. Neurophysiological analysis of piracetam effect on brain excitability. Balkan Pharmacological Days, Varna, Bulgaria, 1982, Abstract in the Proceedings, p.51.

6. Champagnat, J., Morin M.-P. Denavit-Saubie M., Moyanova S. The effect of pentobarbital anaesthesia on the pharmacological responsiveness of bulbar respiratory related neurones to acetylcholine and GABA. Intern. Symp. "Central Neural Production of Periodic Respiratory Movements, Lake Bluff, Illinois, U.S.A., 1982. Abstract in the Proceedings, p.176

7. Moyanova S., Rousseva S., Dimov S. The effect of kainic acid microinjections into nucleus raphe dorsalis on brain excitability level in cat. Annual Meeting of European Brain and Behaviour Society, Marseille, France,1983. Abstract in Behav. Brain Research 12(2), 1984, 213-214.

8. Ta L., Moyanova S. Effect of electroacupuncture on the responses of substantia nigra neurones to pain in cats. Annual Meeting of the European Brain and Behaviour Society, Oxford, England, 1985. Abstract in Behav. Brain Research, 20(1), 1986, p.151.

9. Dikova M., Moyanova S., Nikolova M. Quantitative EEG analysis of the effects of nicergoline in some brain structures after asphyxic anoxia in cats. Intern. Symposium on Hypoxia, Berlin, Germany, 1988. Abstract in the Proceedings, p.21.

10. Nikolov R., Maslarova J., Semkova I., Moyanova S. Endothelin-1 (ET-1) and endothelin-3 (ET-3) cause antinociception. 34th Spring Meeting of "Deutsche Gesellschaft fur Pharmakologie und Toxikologie", Mainz, Germany, 1993. Abstract in the Proceedings and in Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl to Vol. 347, 1993, R141.

11. Moyanova S., Kirov R., Kortenska L. The 5-HT2 antagonist ritanserin has different effects on the spectral characteristics of frontal cortex EEG in young and old freely-moving rats. 16th European Winter Conference on Brain research, Serre-Chevalier, France, 1996. Abstract in the Proceedings.

12. Kirov R., Moyanova S. Effects of 5-hydroxytryptamine2 antagonists on the intermediate stage of sleep in rats during aging. XXXIII Intern. Congress of Physiological Sciences, St. Petersburg, 1997, Russia, Abstract in the Proceedings, P104.10.

13. Moyanova S., Kortenska L., Kirov R. High-voltage EEG spindles, aging and 5-HT2 antagonism. XXXIII Intern. Congress of Physiological Sciences, St. Petersburg, Russia, 1997, Abstract in the Proceedings, P075.38.

14. Moyanova S., Kortenska L., Mitreva R. Electroencephalographic monitoring after treatment with the N-methyl-D-aspartate receptor antagonist MK-801 in the endothelin-1 model of focal cerebral ischemia in rats. East-European symposium "Central and Peripheral Synaptic Transmission", Varna, Bulgaria, 2005. Abstract in: Autonomic & Autocoid Pharmacology, 26, 2006, P.21.

15. Pashova V., Moyanova S., Mitreva R., Kortenska L. How important is age in the model of focal ischemia, induced by endothelin-1 injected near the middle cerebral artery in rats? 29th Balkan Medical Week. Ecology, Man, Health, 2006, Varna, Bulgaria.


Other publications:
1. Moyanova S. Bulgaria. In: D'Avanzo C.E. & Geissler E.M. Cultural Health Assessment. Third Edition, Mosby's Pocket Guide Series. Mosby, Elsevier Science, 2003, 119-125.

Authored paper presentations (oral or poster) at the following International Conferences and Congresses:
1. XXVII Intern. Congress of Physiol. Sciences, Paris, 1977
2. XXVIII Intern. Congress of Physiol. Sciences, Budapest, 1980.
3. Annual General Conference of the European Brain and Behaviour Society,London, England, 1981
4. Balkan Pharmacological Days, Varna, 1982
5. Intern. Symp. "Central Neural Production of Periodic Respiratory Movements, Lake Bluff, Illinois, 1982
6. Annual Meeting of European Brain and Behaviour Society, Marseille, France,1983
7. Journee Communes de la Societe d'Electroencephalographie et de Neurophysiologie Clinique et de la Ligue Francaise contre l'Epilepsie,Paris, France, 1983.
8. Annual Meeting of the European Brain and Behaviour Society, Oxford, England, 1985
9. Intern. Symposium on Hypoxia, Berlin, Germany, 1988
10. 34th Spring Meeting of "Deutsche Gesellschaft fur Pharmakologie und Toxikologie", Mainz, Germany, 1993.
11. 16th European Winter Conference on Brain research, Serre-Chevalier, France, 1996.
12. XXXIII Intern. Congress of Physiological Sciences, St. Petersburg, 1997
13. East-European Symposium "Central and Peripheral Synaptic Transmission" Varna, Bulgaria, 2005.

Kirov R, Moyanova S
Distinct sleep-wake stages in rats depend differentially on age.
Neurosci Lett. 2002 Apr 5;322(2):134-6.
Abstract

Moyanova SG, Kirov RK, Kortenska LV
Age-related changes in neocortical high-voltage spindles and alpha EEG power during quiet waking in rats.
Int J Neurosci. 2002 Apr;112(4):473-87.
Abstract

Moyanova S, Kortenska L, Kirov R, Iliev I
Quantitative electroencephalographic changes due to middle cerebral artery occlusion by endothelin 1 in conscious rats.
Arch Physiol Biochem. 1998 Dec;106(5):384-91.
Abstract

Moyanova S, Kortenska L, Kirov R
High-voltage electroencephalogram spindles in rats, aging and 5-HT2 antagonism.
Brain Res. 1998 Mar 9;786(1-2):55-63.
Abstract

Kirov R, Moyanova S
Age-related effect of ritanserin on the sleep-waking phases in rats.
Int J Neurosci. 1998 Apr;93(3-4):265-78.
Abstract

Moyanova S, Kortenska L, Kirov R
High-voltage electroencephalogram spindles in rats, aging and 5-HT2 antagonism.
Brain Res. 1998 Mar 9;786(1-2):55-63.
Abstract

Moyanova S, Kirov R, Ivanova V
Power spectral electroencephalogram analysis of the effects of ritanserin in freely moving rats during quiet waking.
Methods Find Exp Clin Pharmacol. 1997 Nov;19(9):605-11.
Abstract

Kirov R, Moyanova S
Ritanserin-induced changes in sleep-waking phases in rats.
Acta Physiol Pharmacol Bulg. 1995;21(4):87-92.
Abstract

Moyanova S, Riche D
Injections of kainic acid into the raphe dorsal nucleus in freely moving cats: electroencephalographic, behavioral and histopathological consequences.
Methods Find Exp Clin Pharmacol. 1992 Jan-Feb;14(1):49-60.
Abstract

Moyanova S, Riche D
Effect of kainic acid injected into raphe dorsal nucleus on sleep stages in cats.
Acta Neurobiol Exp (Wars). 1991;51(3-4):107-14.
Abstract

Dikova M, Moyanova S, Nikolova M
Quantitative EEG analysis of the effects of nicergoline in some brain structures after asphyxic anoxia in cats.
Biomed Biochim Acta. 1989;48(2-3):S227-30.
Abstract

Moyanova S, Ta L
Dorsal raphe stimulation modulates responses of substantia nigra, pars reticulata neurons to painful stimulation.
Acta Physiol Pharmacol Bulg. 1988;14(2):24-32.
Abstract

Moyanova S, Dimov S, Ivanova A
Kainic acid microinjected into the cat raphe dorsal nucleus modulates the somatosensory evoked potentials and their cycles of excitability.
Neuroscience. 1987 Jul;22(1):83-9.
Abstract

Moyanova S, Rousseva S, Dimov S
Changes in the EEG-reactions to repetitive peripheral and central electrical stimulation by intraraphedorsal kainic acid in the cat.
Methods Find Exp Clin Pharmacol. 1987 Jan;9(1):39-47.
Abstract

Moyanova S, Rousseva S, Ivanova A, Dimov S
Intraraphedorsal kainic acid induces paroxysmal electroencephalographic changes in some brain structures of cats.
Exp Neurol. 1986 Jul;93(1):98-109.
Abstract

Moyanova S, Dimov S
Modulation of visual excitability cycles in some brain structures by high-frequency stimulation of raphe dorsal nucleus in cats.
Acta Physiol Pharmacol Bulg. 1986;12(1):17-25.
Abstract

Moyanova S, Nikolov R, Dimov S
Effect of piracetam on the electrocorticogram after traumatic brain oedema in cats.
Methods Find Exp Clin Pharmacol. 1985 Dec;7(12):623-6.
Abstract

Moyanova S
Rhythmic afterpotentials in relation to pre-stimulus barbiturate spindle-like activity. Macro- and microelectrode investigations.
Acta Physiol Pharmacol Bulg. 1983;9(1):12-20.
Abstract

Champagnat J, Denavit-Saubie M, Moyanova S, Rondouin G
Involvement of amino acids in periodic inhibitions of bulbar respiratory neurones.
Brain Res. 1982 Apr 15;237(2):351-65.
Abstract

Moyanova S, Atsev E, Maloletnev VI
Background neuronal activity in cat somatosensory cortex before and after VPL damage. Histogram and taxonomic analysis.
Acta Physiol Pharmacol Bulg. 1978;4(4):43-50.
Abstract